Approach to Diagnosis and Management of Osteosarcoma


  • Rhyan Darma Saputra Sebelas Maret University



primary bone tumors:, malignant:, osteosarcoma:


In children and adolescents, osteosarcoma is a primary bone malignancy of mesenchymal origin. Osteosarcoma also occurs in an older age spectrum (>65 years) because of its association with abnormal bone growth as seen in Paget disease. At a younger age, the incidence of osteosarcoma is associated with rapid bone growth in adolescents. Although the pathophysiology is related to several factors, the exact cause is still unknown. Survival rates are expected to improve with treatment consisting of a combination or one of recently developed surgical resection, chemotherapy, and targeted immunotherapy. In this review article, we focus on the etiology and pathogenesis associated with the diagnosis and short-term and long-term management of osteosarcoma, including newly identified agents such as targeted immunotherapy.1,2


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