Bone, a mineralized connective tissue that is highly dynamic, complex and vascularized, is unlike other tissues; when injured, such tissue does not form scar; instead, it heals and remodels throughout life. However, bone has limited regenerative capacity; bone can only repair itself when the injury is not extensive. When the defect is too large, bone may not be able to repair itself without treatment. In this review, we discuss the biology and physiology of bone and bone healing.
Materials and methods