A lifelong story: a case report of a successfully treated femoral shaft infected nonunion

Authors

  • Iman Solichin Spine Consultant, Department of Orthopaedic and Traumatology, Faculty of Medicine Indonesia University, Orthopaedic Purwokerto Hospital
  • Prima Enky Merthana Resident, Department of Orthopaedic and Traumatology, Faculty of Medicine Indonesia University, Orthopaedic Purwokerto Hospital
  • Felais Hediyanto Pradana Resident, Department of Orthopaedic and Traumatology, Faculty of Medicine Indonesia University, Orthopaedic Purwokerto Hospital
  • Nurmansyah Hatta Dwiputra Resident, Department of Orthopaedic and Traumatology, Faculty of Medicine Indonesia University, Orthopaedic Purwokerto Hospital

DOI:

https://doi.org/10.31282/joti.v3n2.59

Keywords:

non-union, femur, bone graft, infection control

Abstract

Introduction: Fracture healing is a very important clinical event for fracture-patients and for the doctors who treat them. Many factors can interfere with bone healing. The interference may cause delayed union or even nonunion. Nonunion management may cause financial and disability problems to the patient. Diamond concept taught us the importance of bone healing nature. In this case report, we will present the importance of diamond concept in the treatment of a nonunion case.

Case Report: We present a 21-year-old obese-heavy smoker-male with chief complaint of pain on the left thigh since a year ago and was diagnosed with infected nonunion of the left femur. The patient had a history of moderate head injury and closed fracture of the left femur as the result of motor vehicle accident. He was treated in the first hospital by open reduction and internal fixation (ORIF) with plate and screw. Unfortunately, the pain still persisted and the implant was broken. Five months after the first surgery, he underwent another surgery in the second hospital and had an ORIF revision with plate and screw. Four months after the surgery, the wound was not healed, the pain still persisted and the implant was broken again. The patient came to our center, and we performed debridement, ORIF revision with longer plate, intraoperative deep specimen culture, decortication, and bone grafting. Empirical antibiotics by culture was given postoperatively and specified antibiotics was given by culture results. The wound healed, but the pain still persisted and in 8 months, the implant was broken once more. The patient underwent another surgery and had an ORIF revision with plate and screw and bone grafting in our center. In another seven months, finally, the left femur was joined.

Results: Seven months after the last surgery, clinical and radiological union were achieved, and there was no sign of infection. The patient was quite happy with the result eventhough with a leg length discrepancy. He can do his daily activities with additional footwear.

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References

Bhandari M, Fong K, Sprague S, Williams D, Petrisor B. Variability in the definition and perceived causes of delayed unions and nonunions: A cross-sectional, multinational survey of orthopaedic surgeons. J Bone Jt Surg - Ser A. 2012 Aug 1;94(15):e109(1).

Fayaz HC, Giannoudis P V., Vrahas MS, Smith RM, Moran C, Pape HC, et al. The role of stem cells in fracture healing and nonunion. Int Orthop. 2011 Nov;35(11):1587–97.

Hak DJ, Fitzpatrick D, Bishop JA, Marsh JL, Tilp S, Schnettler R, et al. Delayed union and nonunions: Epidemiology, clinical issues, and financial aspects. Injury [Internet]. 2014;45(SUPPL. 2):S3--S7. Available from: http://dx.doi.org/10.1016/j.injury.2014.04.002

Andrzejowski P, Giannoudis P V. The ‘diamond concept’ for long bone non-union management. J Orthop Traumatol. 2019 Dec 1;20(1):21.

Giannoudis P V., Einhorn TA, Marsh D. Fracture healing: The diamond concept. Injury. 2007 Sep;38(4 SUPPL.).

Ollivier M, Gay AM, Cerlier A, Lunebourg A, Argenson JN, Parratte S. Can we achieve bone healing using the diamond concept without bone grafting for recalcitrant tibial nonunions? Injury. 2015 Jul 1;46(7):1383–8.

Elliott DS, Newman KJH, Forward DP, Hahn DM, Ollivere B, Kojima K, et al. A unified theory of bone healing and nonunion. Bone Jt J. 2016;98B(7):884–91.

Kanakaris NK, Tosounidis TH, Giannoudis P V. Surgical management of infected non-unions: An update. Injury. 2015 Nov 1;46:S25–32.

Ekegren CL, Edwards ER, de Steiger R, Gabbe BJ. Incidence, costs and predictors of non-union, delayed union and mal-union following long bone fracture. Int J Environ Res Public Health. 2018 Dec 13;15(12).

Mills LA, Aitken SA, Simpson AHRW. The risk of non-union per fracture: current myths and revised figures from a population of over 4 million adults. Acta Orthop. 2017 Jul 4;88(4):434–9.

Dahabreh Z, Dimitriou R, Giannoudis P V. Health economics: A cost analysis of treatment of persistent fracture non-unions using bone morphogenetic protein-7. Injury. 2007;38(3):371–7.

An S. AO Principles of Fracture Management. Vol 118.; 2018. doi:10.1080/00015458.2018.1467124

Heitemeyer U, Hierholzer G. Bridging osteosynthesis in closed compound fractures of the femur shaft. Aktuelle Traumatol. 1985;15(5):205-9.

Somford MP, van den Bekerom MPJ, Kloen P. Operative treatment for femoral shaft nonunions, a systematic review of the literature. Strateg Trauma Limb Reconstr. 2013 Aug;8(2):77–88.

Khan SN, Cammisa FP, Sandhu Harvinder S, Diwan AD, Girardi FP. The biology of bone grafting. J Am Acad Orthop Surg. 2005;13(1):77–86.

Sen MK, Miclau T. Autologous iliac crest bone graft: Should it still be the gold standard for treating nonunions? Injury. 2007 Mar;38(SUPPL. 1).

Nauth A, Lee M, Gardner MJ, Brinker MR, Warner SJ, Tornetta P, et al. Principles of Nonunion Management: State of the Art. J Orthop Trauma. 2018 Mar 1;32:S52–7.

Olszewski D, Streubel PN, Stucken C, Ricci WM, Hoffmann MF, Jones CB, et al. Fate of patients with a “Surprise” positive culture after nonunion surgery. J Orthop Trauma. 2016 Jan 1;30(1):e19–23.

McKee MD, Li-Bland EA, Wild LM, Schemitsch EH. A prospective, randomized clinical trial comparing an antibiotic- impregnated bioabsorbable bone substitute with standard antibiotic-impregnated cement beads in the treatment of chronic osteomyelitis and infected nonunion. J Orthop Trauma. 2010 Aug;24(8):483–90.

Stafford PR, Norris BL. Reamer-irrigator-aspirator bone graft and bi Masquelet technique for segmental bone defect nonunions: A review of 25 cases. Injury. 2010 Nov;41(SUPPL. 2).

Additional Files

Published

2021-08-01