Time to surgery increases pre-operative il-6 and fibrinogen levels in elderly patient with proximal femoral fracture
DOI:
https://doi.org/10.31282/joti.v2n1.31Keywords:
proximal femoral fracture, elderly patients, time to surgery, Interleukin-6, fibrinogenAbstract
Introduction:
Proximal femoral fractures are often found in elderly patients who often suffer from other diseases too. Therefore, comprehensive perioperative management is needed. Preparation for pre-operation will result in a longer waiting time than the time recommended in general. Time to surgery is associated with an increased risk of inflammation and thromboembolism, but many studies show contradictory results.
Methods:
to find out the correlation between time to surgery and interleukin-6 and fibrinogen levels pre-operatively in elderly patients with proximal femoral fractures. This study was an analytic cross-sectional study in 31 elderly patients with proximal femoral fractures. Interleukin-6 and fibrinogen levels were measured one hour before surgery.
Results :
Of the 31 patients aged ≥ 60 years with a proximal femoral fracture, the average age was 74 years old and the incidence of fracture was most common in women compared to men. The time to surgery is determined from the time the trauma occurred until surgery. There is a significant correlation between time to surgery and IL-6 levels (r 0.673; p <0.05). A significant correlation also found between time to surgery and fibrinogen levels (r 0.747; p <0.05).
Conclusion:
From the results of statistical analysis, it was concluded that the time to surgery was significantly associated with an increase in Interleukin-6 as an inflammatory marker and also with fibrinogen as a possible marker of venous thromboembolism.
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References
Mittal, R. & Banerjee, S. (2012). Proksimal femoral fractures: Principles of management and review of literature. Journal of Clinical Orthopaedics and Trauma. 3 (1). Pp. 15–23.
Librero J., Peiro S., Leutscher E., Merlo J., Bernal-Delgado E., Ridao M., Martinez-Lizaga N., Sanfelix-Gimeno G. (2012). Timing of Surgery for Panggul Fracture and In-Hospital Mortality: a Retrospective Population-Based Cohort Study in The Spanish National Health System. BMC Health Services Research. 12 (15). Pp. 1-11.
Lee, D.J. & Elfar, J.C. (2014). Timing of Panggul Fracture Surgery in the Elderly. Geriatric Orthopaedic Surgery & Rehabilitation. 5 (3). p.pp. 138–140.
Karakaya, C., Noyan, T., Ekin, S. & Babayev, E. (2013). Serum IL-6 and CRP levels in patients with trauma involving low-extremity bone fractures. Eastern Journal of Medicine. 18 (4). Pp. 176–180.
Smith, E.B., Parvizi, J. & Purtill, J.J. (2011). Delayed surgery for patients with femur and panggul fractures-risk of deep venous thrombosis. Journal of Trauma. 70 (6). Pp. E113–E116.
Petros R.S.B., Ferreira P.E.V., Petros R.S.B. (2017). Influence of proximal femur fractures in the autonomy and mortality of elderly patients submitted to osteosynthesis with cephalomedullary nail. Rev Bras Ortop. 52(S1). Pp.57-62.
Smektala R., Endres H.G., Dasch B., Maier C., Trampisch HJ., Bonnaire F., Pientka L. (2008). The effect of time-to-surgery on outcome in elderly patients with proximal femoral fractures. BMC Musculoskeletal Disorders.9 (171). Pp. 1-9.
Tian-Sheng S., Jian-Zheng Z., Zhi L. (2016). Current view on elderly panggul fracture and inflammatory response. Austin J Orthopade & Rheumatol. 3 (2). Pp.1-3.
Reikeras O & Borgen P. (2014). Activation of markers of inflammation, coagulation, and fibrinolysis in muskuloskeletal gtrauma. Plos.Pp.1-6
Toamzic A.W et al. (2016). Inflammatory Markers Change with Age, but do not Fall Beyond Reported Normal Ranges. Arch. Immunol. Ther. 64:249-254
Kapoor C.S., Mehta A.K., Patel K., Golwala P.P. (2016). Prevalence of deep vein thrombosis in patients with lower limb trauma. JCOT. 7S. Pp. 220-224.
