The effect of ascorbic acid irrigation during debridementon the colony count of staphylococcus aureus and interleukin-6 blood count in grade ii open fracture of long bone
DOI:
https://doi.org/10.31282/joti.v2n1.34Keywords:
Open fracture, Staphylococcus aureus, IL-6, ascorbic acidAbstract
Introduction:
Infection in open fractures is still a problem that can not be fully managed. Various types of studies have been conducted to find an effective and efficient solution to wash open fracture wounds. This study analyzed the effectiveness of ascorbic acid irrigation in reducing Staphylococcus aureus colony and IL-6 in open fractures grade II.
Methods:
This study was an experimental study with pre- and post-test control group design. In this study, the colony count of Staphylococcus aureus and IL-6 in open fracture was treated with additional irrigation of 10mg//mL ascorbic acid during debridement. This study included 24 subjects with Gustillo type II open fractures, which were divided into 2 groups.
Results:
Statistical analysis using Wilcoxon test showed that there was no significant difference (p> 0.05) in the reduction of Staphylococcus aureus colonies (p=0.308) and IL-6 (p=0.239) blood count between the Control Group and the Treatment Group.
Conclusion:
Ascorbic acid irrigation did not decrease Staphylococcus aureus colony and IL-6 blood count in open fracture grade II of long bone.
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References
Nuebaueret al. Open Fractures and Infection: Current Concept Review. Acta Chirurgiae Orthopaedicae Et TraumatologiaeČechosl., 73, 2006
Seekamp A, Köntopp H, Schandelmaier P, Krettek C, Tscherne H. Bacterial Cultures and Bacterial Infection in Open Fractures. European Journal of Trauma 2000;26(3), 131-138.
Ojo OD, Oluwadiya KS, Ikem IC, Oginni LM, Ako-Nai AK, Daniel FV. Superficial swab cultures in open fracture management: insights from a resource-poor setting. Journal of Wound Care. 2010;19(10),432-438.
Buteera AM dan Nyimana J. Principles of Management of Open Fractures. East and Central African Journal of Surgery, Volume 14 Number 2 – July/August 2009
Halawi JM dan Morwood MP. Acute Management of Open Fracture: An Evidence Based Review. Orthopedics. November 2015 | Volume 38 • Number 11. 2015; 38(11):E1025- E1033
Dirschl, DR.Surgical Irrigation of Open Fractures — A Change in Practice? The New England Journal of Medicine, October 9, 2015
Olufemi, et al. Irrigation solutions in open fractures of the lower extremities: evaluation of isotonic saline and distilled water. SICOT J, 2017.
Santos, et al. The effectiveness of cleansing solutions for wound treatment: a systematic review. Journal of Nursing Referência.Série IV - no 9 - apr./may/jun. 2016. pp.133-130
Crowley et al.Irrigation of the wounds in open fractures. J Bone Joint Surg [Br]2007;89-B:580-5
Hadiwidjaja, G. Pencucian Tambahan Larutan Antibiotik (Neomisin Basitrasin)Atau Larutan Antiseptik (Povidon odin) Menurunkan Jumlah KoloniS taphylococcus Aureus Pada Fraktur Terbuka Pasca Debridement Dan Fiksasi Internal. 2015
Suslovitcthet al. Analysis of Staphylococcus aureus and Escherichia coli inhibition from varying concentrations of Vitamin C. Acta Spartae, Vol. 1 No. 1 2015. Pages 1–3
Fu,et al. Development of vitamin C irrigation saline to promote graft healing in anterior cruciate ligament reconstruction. Journal of Orthopaedic Translation (2013) 1, 67-77
Ellulu, et al. Effect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trial. Drug Design, Development and Therapy, 2015:9 3405–3412
Chambialet al. Vitamin C in Disease Prevention and Cure: An Overview. Ind J Clin Biochem (Oct-Dec 2013) 28(4):314–328
Mirikovaet al. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. Journal of Translational Medicine, 2012, 10:189
